Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris.

Healthy Individuals in Patients with Pemphigus Vulgaris and T Cell Recognition of Desmoglein 3 Peptides

Serum Levels of Interleukin 17 in Patients with Pemphigus and Healthy Subjects

Introduction: Pemphigus is a relatively rare autoimmune bullous disease involving skin and mucous epithelia. The disease occurs as a result of production of auto-antibodies against inter-cellular epithelia especially cadherin and desmoglein. Interleukin 17 (IL-17) is one of the specific cytokines of T helper. IL-17 plays an important role in delayed type reaction and recruits neutrophils and mo...

Comparison of Serum Level of Antiphospholipid Antibodies and Homocysteine in Patients with Pemphigus Vulgaris and Healthy Subjects: A Case-Control Study

Introduction: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membrane. Antiphospholipid antibodies are a group of autoantibodies found in patients with autoimmune diseases. Due to the risk for thrombotic events in autoimmune diseases, we decided to evaluate the correlation between pemphigus vulgaris and predictive elements of atherothrombosis including antiphospho...

Elevated Levels of Interleukin-23 in Sera of Patients with Pemphigus Vulgaris

Background: Pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. Objectives: To investigate the potential role of IL-23 in pemphigus vulgaris. Methods: In this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and...

Quality of life evaluation in patients with pemphigus vulgaris

Background: Pemphigus is a rare autoimmune disease causedby autoantibodies against desmoglein. It clinically presents withpainful blisters and erosions on the skin and mucous membranes.Few studies have been conducted on the quality of life inpemphigus patients which have all indicated the strong impactof the disease on emotional and physical status of the patients.According to evident differenc...